Nuclear factor B signaling regulates neuronal morphology and cocaine reward
نویسندگان
چکیده
Scott J. Russo,1 Matthew B. Wilkinson,1* Michelle S. Mazei-Robison,1* David M. Dietz,1 Ian Maze,1 Vaishnav Krishnan,2 William Renthal,2 Ami Graham,2 Shari G. Birnbaum,2 Thomas A. Green,2 Bruce Robison,2 Alan Lesselyong,2 Linda I. Perrotti,2 Carlos A. Bolaños,2 Arvind Kumar,2 Michael S. Clark,3 John F. Neumaier,3 Rachael L. Neve,4 Asha L. Bhakar,5 Philip A. Barker,5 and Eric J. Nestler1 1Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, 2Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, 3Harborview Medical Center, University of Washington, Seattle, Washington 98104, 4Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and 5Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
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Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.
Although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (NAc) neurons have been correlated with behavioral sensitization, the molecular pathways governing these structural changes, and their resulting behavioral effects, are poorly understood. The transcription factor, nuclear factor kappa B (NFkappaB), is rapidly activated by diverse stimuli and regulates expression o...
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